Drugs and manners of administration that meet the 42 month clock

Page last updated: 22 October 2025

This page lists the drugs and manners of administration (MoA) that will meet the 42 month clock for the 2026 April Cycle. A drug/MoA will meet the 42 month clock if the brand’s pharmaceutical item has been on F2 for at least 42 months, and at least 30 months have passed since the first price disclosure price reduction for any brand of the same drug/MoA.

Brands of a drug/MoA which have met the 42 month clock will satisfy the ‘designated brand’ criteria under s99ADHC(1)(a) of the National Health Act 1953 (the Act). Under s99ADH(1)(c) of the Act, designated brands with an AEMP of more than $4 will be subject to a 30% Unadjusted Price Reduction (UPR), OR a 10% UPR, if there has been discounting averaging at least 12.5% over the last 3 data collection periods including the one for which calculations are performed and there has not been a price reduction under s99ADH of the Act.

Drug/MoAs that have not met the 42 month clock may satisfy criteria for a future cycle. Updates will be published in April and October of each year.

Further information on the 42 month clock as well as the application of the 30% threshold is available in the Price Disclosure Guidelines.

Drugs and manners of administration that meet the 42 month clock for the 2026 April Cycle:

Legal Instrument Drug

Legal Instrument MoA

Meets 42 month clock

Abacavir with lamivudine

Oral

Yes

Abatacept

Injection

Yes

Acamprosate

Oral

Yes

Acarbose

Oral

Yes

Aciclovir

Application to the eye

Yes

Aciclovir

Oral

Yes

Acitretin

Oral

Yes

Adalimumab

Injection

No

Adefovir

Oral

No

Adrenaline (epinephrine)

Injection

Yes

Alendronic acid

Oral

Yes

Alendronic acid with colecalciferol

Oral

Yes

Alendronic acid with colecalciferol and calcium

Oral

No

Allopurinol

Oral

Yes

Alprazolam

Oral

Yes

Ambrisentan

Oral

No

Amiodarone

Oral

Yes

Amisulpride

Oral

Yes

Amitriptyline

Oral

Yes

Amlodipine

Oral

Yes

Amlodipine with atorvastatin

Oral

Yes

Amlodipine with valsartan

Oral

Yes

Amlodipine with valsartan and hydrochlorothiazide

Oral

Yes

Amoxicillin

Oral

Yes

Amoxicillin with clavulanic acid

Oral

Yes

Ampicillin

Injection

Yes

Anastrozole

Oral

Yes

Apomorphine

Injection

Yes

Aprepitant

Oral

No

Aripiprazole

Injection

Yes

Aripiprazole

Oral

Yes

Arsenic

Injection

No

Aspirin

Oral

No

Atazanavir

Oral

Yes

Atenolol

Oral

Yes

Atomoxetine

Oral

Yes

Atorvastatin

Oral

Yes

Atovaquone with proguanil

Oral

No

Azacitidine

Injection

Yes

Azacitidine

Oral

No

Azathioprine

Oral

Yes

Azithromycin

Oral

Yes

Baclofen

Oral

Yes

Baclofen

Injection

Yes

Bendamustine

Injection

No

Betamethasone

Application

Yes

Betamethasone

Injection

No

Betaxolol

Application to the eye

Yes

Bevacizumab

Injection

No

Bicalutamide

Oral

Yes

Bimatoprost

Application to the eye

Yes

Bisacodyl

Oral

No

Bisacodyl

Rectal

Yes

Bisoprolol

Oral

Yes

Bivalirudin

Injection

Yes

Bleomycin

Injection

Yes

Bortezomib

Injection

No

Bosentan

Oral

Yes

Brimonidine

Application to the eye

Yes

Brinzolamide

Application to the eye

Yes

Bromocriptine

Oral

No

Budesonide with formoterol

Inhalation by Mouth

Yes

Buprenorphine

Injection

Yes

Buprenorphine

Sublingual

Yes

Buprenorphine

Transdermal

Yes

Bupropion

Oral

No

Cabazitaxel

Injection

No

Cabergoline

Oral

Yes

Calcipotriol with betamethasone

Application

Yes

Calcitriol

Oral

Yes

Candesartan

Oral

Yes

Candesartan with hydrochlorothiazide

Oral

Yes

Capecitabine

Oral

Yes

Captopril

Oral

Yes

Carbamazepine

Oral

Yes

Carbimazole

Oral

No

Carbomer

Application to the eye

Yes

Carboplatin

Injection

Yes

Carvedilol

Oral

Yes

Cefaclor

Oral

Yes

Cefalexin

Oral

Yes

Cefalotin

Injection

No

Cefazolin

Injection

Yes

Cefepime

Injection

Yes

Cefotaxime

Injection

Yes

Ceftriaxone

Injection

Yes

Cefuroxime

Oral

Yes

Celecoxib

Oral

Yes

Certolizumab pegol

Injection

Yes

Chorionic gonadotrophin

Injection

Yes

Ciclosporin

Oral

Yes

Ciclosporin

Application to the eye

No

Cimetidine

Oral

No

Cinacalcet

Oral

No

Ciprofloxacin

Application to the eye

Yes

Ciprofloxacin

Oral

Yes

Cisplatin

Injection

Yes

Citalopram

Oral

Yes

Clarithromycin

Oral

Yes

Clindamycin

Oral

Yes

Clomifene

Oral

No

Clomipramine

Oral

Yes

Clonazepam

Oral

Yes

Clonidine

Oral

Yes

Clopidogrel

Oral

Yes

Clopidogrel with aspirin

Oral

Yes

Clozapine

Oral

Yes

Codeine with paracetamol

Oral

Yes

Colchicine

Oral

Yes

Cromoglycic acid

Inhalation by mouth

Yes

Cyproterone

Oral

Yes

Darunavir

Oral

No

Dasatinib

Oral

No

Deferasirox

Oral

No

Desferrioxamine

Injection

Yes

Desvenlafaxine

Oral

Yes

Dexamethasone

Application to the eye

No

Dexamethasone

Implantation

No

Dexamethasone

Injection

No

Dexamethasone

Oral

Yes

Dexamethasone with framycetin and gramicidin

Application to the ear

Yes

Diazepam

Oral

Yes

Diclofenac

Oral

Yes

Dicloxacillin

Oral

Yes

Digoxin

Oral

Yes

Diltiazem

Oral

Yes

Dimethyl fumarate

Oral

No

Diphenoxylate with atropine

Oral

Yes

Dipyridamole with Aspirin

Oral

No

Docetaxel

Injection

Yes

Domperidone

Oral

No

Donepezil

Oral

Yes

Dorzolamide

Application to the eye

Yes

Dorzolamide with timolol

Application to the eye

Yes

Dosulepin

Oral

Yes

Doxorubicin

Injection/intravesical

Yes

Doxorubicin - pegylated liposomal

Injection

Yes

Doxycycline

Oral

Yes

Duloxetine

Oral

Yes

Dutasteride

Oral

Yes

Dutasteride with tamsulosin

Oral

Yes

Electrolyte replacement, oral

Oral

Yes

Enalapril

Oral

Yes

Enalapril with hydrochlorothiazide

Oral

Yes

Enoxaparin

Injection

Yes

Entecavir

Oral

Yes

Epirubicin

Injection/intravesical

Yes

Eplerenone

Oral

Yes

Epoprostenol

Injection

Yes

Eprosartan

Oral

Yes

Erlotinib

Oral

No

Erythromycin

Oral

Yes

Escitalopram

Oral

Yes

Esomeprazole

Oral

Yes

Esomeprazole and clarithromycin and amoxicillin

Oral

Yes

Estradiol

Oral

Yes

Estradiol

Transdermal

Yes

Estradiol

Vaginal

No

Etanercept

Injection

Yes

Etoposide

Injection

Yes

Etoposide

Oral

Yes

Everolimus

Oral

Yes

Exemestane

Oral

Yes

Ezetimibe

Oral

Yes

Ezetimibe and rosuvastatin

Oral

Yes

Ezetimibe with atorvastatin

Oral

Yes

Ezetimibe with simvastatin

Oral

Yes

Famciclovir

Oral

Yes

Famotidine

Oral

Yes

Felodipine

Oral

Yes

Fenofibrate

Oral

Yes

Fentanyl

Buccal

Yes

Fentanyl

Transdermal

Yes

Fentanyl

Sublingual

Yes

Filgrastim

Injection

Yes

Fingolimod

Oral

No

Flecainide

Oral

Yes

Flucloxacillin

Injection

Yes

Flucloxacillin

Oral

Yes

Fluconazole

Injection

Yes

Fluconazole

Oral

Yes

Fludarabine

Injection

Yes

Fludarabine

Oral

No

Fludrocortisone

Oral

No

Fluorouracil

Injection

Yes

Fluoxetine

Oral

Yes

Flutamide

Oral

No

Fluticasone propionate

Inhalation by mouth

Yes

Fluticasone propionate with salmeterol

Inhalation by mouth

Yes

Fluvastatin

Oral

No

Fluvoxamine

Oral

Yes

Folinic acid

Injection

Yes

Folinic acid

Oral

No

Follitropin alfa

Injection

Yes

Follitropin beta

Injection

No

Fosaprepitant

Injection

No

Fosinopril

Oral

Yes

Fosinopril with hydrochlorothiazide

Oral

Yes

Fulvestrant

Injection

No

Furosemide

Injection

No

Furosemide

Oral

Yes

Gabapentin

Oral

Yes

Galantamine

Oral

Yes

Ganciclovir

Injection

Yes

Ganirelix

Injection

No

Gefitinib

Oral

Yes

Gemcitabine

Injection

Yes

Gemfibrozil

Oral

Yes

Gentamicin

Application to the eye

No

Gentamicin

Injection

No

Glatiramer

Injection

No

Glibenclamide

Oral

No

Gliclazide

Oral

Yes

Glimepiride

Oral

Yes

Glipizide

Oral

Yes

Glyceryl trinitrate

Buccal/sublingual

Yes

Glyceryl trinitrate

Transdermal

Yes

Granisetron

Injection

Yes

Granisetron

Oral

No

Hydrochlorothiazide with amiloride

Oral

No

Hydrocortisone

Application

Yes

Hydrocortisone

Application to the eye

No

Hydrocortisone

Injection

Yes

Hydrocortisone

Oral

Yes

Hydrocortisone

Rectal

No

Hydromorphone

Injection

Yes

Hydromorphone

Oral

Yes

Hydroxocobalamin

Injection

Yes

Hydroxycarbamide

Oral

Yes

Hydroxychloroquine

Oral

Yes

Hyoscine

Injection

Yes

Hypromellose

Application to the eye

Yes

Hypromellose with carbomer 980

Application to the eye

Yes

Hypromellose with dextran

Application to the eye

Yes

Ibuprofen

Oral

Yes

Icatibant

Injection

No

Idarubicin

Injection

Yes

Imatinib

Oral

Yes

Imipramine

Oral

Yes

Imiquimod

Application

Yes

Indapamide

Oral

Yes

Indometacin

Oral

Yes

Infliximab

Injection

Yes

Insulin glargine

Injection

Yes

Interferon beta-1b

Injection

No

Ipratropium

Inhalation

Yes

Ipratropium

Inhalation by mouth

No

Irbesartan

Oral

Yes

Irbesartan with hydrochlorothiazide

Oral

Yes

Irinotecan

Injection

Yes

Iron polymaltose complex

Injection

No

Isosorbide dinitrate

Oral

No

Isosorbide mononitrate

Oral

Yes

Isotretinoin

Oral

Yes

Itraconazole

Oral

Yes

Ivabradine

Oral

Yes

Ketoprofen

Oral

Yes

Labetalol

Oral

Yes

Lacosamide

Oral

No

Lamivudine

Oral

Yes

Lamivudine with zidovudine

Oral

Yes

Lamotrigine

Oral

Yes

Lanreotide

Oral

No

Lansoprazole

Oral

Yes

Latanoprost

Application to the eye

Yes

Latanoprost with timolol

Application to the eye

Yes

Leflunomide

Oral

Yes

Lenalidomide

Oral

No

Lercanidipine

Oral

Yes

Letrozole

Oral

Yes

Levetiracetam

Oral

Yes

Levodopa with carbidopa

Intra-intestinal

No

Levodopa with carbidopa

Oral

Yes

Levodopa with carbidopa and entacapone

Oral

Yes

Levonorgestrel with ethinylestradiol

Oral

Yes

Levothyroxine

Oral

Yes

Lincomycin

Injection

Yes

Lisinopril

Oral

Yes

Loperamide

Oral

Yes

Losartan

Oral

Yes

Lurasidone

Oral

Yes

Macrogol 3350

Oral

Yes

Medroxyprogesterone

Injection

Yes

Medroxyprogesterone

Oral

Yes

Mefenamic acid

Oral

No

Meloxicam

Oral

Yes

Memantine

Oral

Yes

Mercaptopurine

Oral

No

Mesalazine

Oral

No

Mesalazine

Rectal

No

Metformin

Oral

Yes

Methadone

Oral

Yes

Methenamine

Oral

No

Methotrexate

Injection

Yes

Methotrexate

Oral

Yes

Methyldopa

Oral

Yes

Methylphenidate

Oral

Yes

Methylprednisolone

Application

Yes

Methylprednisolone

Injection

Yes

Metoclopramide

Injection

No

Metoclopramide

Oral

Yes

Metoprolol

Oral

Yes

Metoprolol succinate

Oral

Yes

Metronidazole

Oral

Yes

Mianserin

Oral

Yes

Minocycline

Oral

Yes

Mirtazapine

Oral

Yes

Mitozantrone

Injection

Yes

Moclobemide

Oral

Yes

Modafinil

Oral

Yes

Mometasone

Application

Yes

Montelukast

Oral

Yes

Morphine

Injection

Yes

Morphine

Oral

Yes

Moxonidine

Oral

Yes

Mycophenolic acid

Oral

Yes

Naloxone

Injection

Yes

Naloxone

Nasal

No

Naltrexone

Oral

Yes

Naproxen

Oral

Yes

Nebivolol

Oral

Yes

Nevirapine

Oral

Yes

Nicorandil

Oral

Yes

Nifedipine

Oral

Yes

Nitrazepam

Oral

Yes

Nitrofurantoin

Oral

Yes

Nizatidine

Oral

Yes

Norethisterone

Oral

Yes

Norethisterone with ethinylestradiol

Oral

Yes

Norfloxacin

Oral

Yes

Nortriptyline

Oral

Yes

Octreotide

Injection

Yes

Olanzapine

Injection

Yes

Olanzapine

Oral

Yes

Olmesartan

Oral

Yes

Olmesartan with amlodipine

Oral

Yes

Olmesartan with amlodipine and hydrochlorothiazide

Oral

Yes

Olmesartan with hydrochlorothiazide

Oral

Yes

Omalizumab

Injection

Yes

Omeprazole

Oral

Yes

Ondansetron

Oral

Yes

Oxaliplatin

Injection

Yes

Oxazepam

Oral

Yes

Oxybutynin

Oral

Yes

Oxybutynin

Transdermal

No

Oxycodone

Oral

Yes

Oxycodone

Rectal

No

Paclitaxel

Injection

Yes

Palonosetron

Oral

No

Palonosetron

Injection

No

Pamidronic acid

Injection

Yes

Pantoprazole

Oral

Yes

Paracetamol

Oral

Yes

Paraffin

Application to the eye

Yes

Paraffin with retinol palmitate

Application to the eye

No

Paroxetine

Oral

Yes

Pegfilgrastim

Injection

Yes

Pemetrexed

Injection

Yes

Perindopril

Oral

Yes

Perindopril with amlodipine

Oral

Yes

Perindopril with indapamide

Oral

Yes

Phenoxymethylpenicillin

Oral

Yes

Pilocarpine

Application to the eye

Yes

Pindolol

Oral

No

Pioglitazone

Oral

Yes

Piroxicam

Oral

Yes

Plerixafor

Injection

No

Polyethylene glycol 400 with propylene glycol

Application to the eye

No

Polyvinyl alcohol

Application to the eye

Yes

Pomalidomide

Oral

No

Posaconazole

Oral

No

Potassium chloride

Oral

No

Potassium chloride with potassium bicarbonate

Oral

No

Pramipexole

Oral

Yes

Pravastatin

Oral

Yes

Prazosin

Oral

Yes

Prednisolone

Oral

Yes

Prednisolone

Rectal

Yes

Prednisone

Oral

Yes

Pregabalin

Oral

Yes

Prochlorperazine

Oral

Yes

Propranolol

Oral

Yes

Quetiapine

Oral

Yes

Quinapril

Oral

Yes

Quinine

Oral

No

Rabeprazole

Oral

Yes

Raloxifene

Oral

Yes

Ramipril

Oral

Yes

Ranitidine

Oral

Yes

Rasagiline

Oral

Yes

Riluzole

Oral

Yes

Risedronic acid

Oral

Yes

Risedronic acid and calcium

Oral

No

Risperidone

Injection

Yes

Risperidone

Oral

Yes

Rituximab

Injection

Yes

Rivastigmine

Oral

Yes

Rivastigmine

Transdermal

Yes

Rizatriptan

Oral

Yes

Rosuvastatin

Oral

Yes

Roxithromycin

Oral

Yes

Salbutamol

Inhalation

Yes

Salbutamol

Inhalation by mouth

Yes

Selegiline

Oral

No

Sertraline

Oral

Yes

Sevelamer

Oral

Yes

Sildenafil

Oral

Yes

Simvastatin

Oral

Yes

Sitagliptin

Oral

No

Sitagliptin with metformin

Oral

No

Somatropin

Injection

Yes

Sorbitol with sodium citrate dihydrate and sodium lauryl sulfoacetate

Rectal

No

Sotalol

Oral

Yes

Spironolactone

Oral

Yes

Sucralfate

Oral

No

Sulfasalazine

Oral

Yes

Sumatriptan

Nasal

No

Sumatriptan

Oral

Yes

Sunitinib

Oral

No

Tacrolimus

Oral

Yes

Tadalafil

Oral

Yes

Tamoxifen

Oral

Yes

Telmisartan

Oral

Yes

Telmisartan with amlodipine

Oral

Yes

Telmisartan with hydrochlorothiazide

Oral

Yes

Temazepam

Oral

Yes

Temozolomide

Oral

Yes

Tenofovir

Oral

Yes

Tenofovir with emtricitabine

Oral

Yes

Tenofovir with emtricitabine and efavirenz

Oral

Yes

Terbinafine

Oral

Yes

Teriflunomide

Oral

Yes

Teriparatide

Injection

No

Tetrabenazine

Oral

No

Timolol

Application to the eye

Yes

Tiotropium

Inhalation by Mouth

Yes

Tirofiban

Injection

Yes

Tobramycin

Inhalation by mouth

No

Tobramycin

Application to the eye

Yes

Tobramycin

Injection

Yes

Tobramycin

Inhalation

Yes

Tocilizumab

Injection

Yes

Topiramate

Oral

Yes

Topotecan

Injection

No

Tramadol

Injection

Yes

Tramadol

Oral

Yes

Trandolapril

Oral

Yes

Tranexamic acid

Oral

Yes

Trastuzumab

Injection

Yes

Triamcinolone

Application

Yes

Triamcinolone

Injection

No

Triamcinolone with neomycin, gramicidin and nystatin

Application to the ear

Yes

Trimethoprim

Oral

Yes

Trimethoprim with sulfamethoxazole

Oral

Yes

Tropisetron

Injection

No

Ursodeoxycholic acid

Oral

Yes

Valaciclovir

Oral

Yes

Valganciclovir

Oral

Yes

Valproic acid

Oral

Yes

Valsartan

Oral

Yes

Valsartan with hydrochlorothiazide

Oral

Yes

Vancomycin

Injection

Yes

Vancomycin

Oral

Yes

Varenicline

Oral

No

Venlafaxine

Oral

Yes

Verapamil

Oral

Yes

Vincristine

Injection

No

Vinorelbine

Injection

Yes

Vinorelbine

Oral

Yes

Voriconazole

Oral

Yes

Ziprasidone

Oral

Yes

Zoledronic acid

Injection

Yes

Zolmitriptan

Oral

Yes

Zonisamide

Oral

Yes