Drugs and manners of administration that meet the 42 month clock
Page last updated: 22 October 2025
This page lists the drugs and manners of administration (MoA) that will meet the 42 month clock for the 2026 April Cycle. A drug/MoA will meet the 42 month clock if the brand’s pharmaceutical item has been on F2 for at least 42 months, and at least 30 months have passed since the first price disclosure price reduction for any brand of the same drug/MoA.
Brands of a drug/MoA which have met the 42 month clock will satisfy the ‘designated brand’ criteria under s99ADHC(1)(a) of the National Health Act 1953 (the Act). Under s99ADH(1)(c) of the Act, designated brands with an AEMP of more than $4 will be subject to a 30% Unadjusted Price Reduction (UPR), OR a 10% UPR, if there has been discounting averaging at least 12.5% over the last 3 data collection periods including the one for which calculations are performed and there has not been a price reduction under s99ADH of the Act.
Drug/MoAs that have not met the 42 month clock may satisfy criteria for a future cycle. Updates will be published in April and October of each year.
Further information on the 42 month clock as well as the application of the 30% threshold is available in the Price Disclosure Guidelines.
Drugs and manners of administration that meet the 42 month clock for the 2026 April Cycle:
Legal Instrument Drug |
Legal Instrument MoA |
Meets 42 month clock |
---|---|---|
Abacavir with lamivudine |
Oral |
Yes |
Abatacept |
Injection |
Yes |
Acamprosate |
Oral |
Yes |
Acarbose |
Oral |
Yes |
Aciclovir |
Application to the eye |
Yes |
Aciclovir |
Oral |
Yes |
Acitretin |
Oral |
Yes |
Adalimumab |
Injection |
No |
Adefovir |
Oral |
No |
Adrenaline (epinephrine) |
Injection |
Yes |
Alendronic acid |
Oral |
Yes |
Alendronic acid with colecalciferol |
Oral |
Yes |
Alendronic acid with colecalciferol and calcium |
Oral |
No |
Allopurinol |
Oral |
Yes |
Alprazolam |
Oral |
Yes |
Ambrisentan |
Oral |
No |
Amiodarone |
Oral |
Yes |
Amisulpride |
Oral |
Yes |
Amitriptyline |
Oral |
Yes |
Amlodipine |
Oral |
Yes |
Amlodipine with atorvastatin |
Oral |
Yes |
Amlodipine with valsartan |
Oral |
Yes |
Amlodipine with valsartan and hydrochlorothiazide |
Oral |
Yes |
Amoxicillin |
Oral |
Yes |
Amoxicillin with clavulanic acid |
Oral |
Yes |
Ampicillin |
Injection |
Yes |
Anastrozole |
Oral |
Yes |
Apomorphine |
Injection |
Yes |
Aprepitant |
Oral |
No |
Aripiprazole |
Injection |
Yes |
Aripiprazole |
Oral |
Yes |
Arsenic |
Injection |
No |
Aspirin |
Oral |
No |
Atazanavir |
Oral |
Yes |
Atenolol |
Oral |
Yes |
Atomoxetine |
Oral |
Yes |
Atorvastatin |
Oral |
Yes |
Atovaquone with proguanil |
Oral |
No |
Azacitidine |
Injection |
Yes |
Azacitidine |
Oral |
No |
Azathioprine |
Oral |
Yes |
Azithromycin |
Oral |
Yes |
Baclofen |
Oral |
Yes |
Baclofen |
Injection |
Yes |
Bendamustine |
Injection |
No |
Betamethasone |
Application |
Yes |
Betamethasone |
Injection |
No |
Betaxolol |
Application to the eye |
Yes |
Bevacizumab |
Injection |
No |
Bicalutamide |
Oral |
Yes |
Bimatoprost |
Application to the eye |
Yes |
Bisacodyl |
Oral |
No |
Bisacodyl |
Rectal |
Yes |
Bisoprolol |
Oral |
Yes |
Bivalirudin |
Injection |
Yes |
Bleomycin |
Injection |
Yes |
Bortezomib |
Injection |
No |
Bosentan |
Oral |
Yes |
Brimonidine |
Application to the eye |
Yes |
Brinzolamide |
Application to the eye |
Yes |
Bromocriptine |
Oral |
No |
Budesonide with formoterol |
Inhalation by Mouth |
Yes |
Buprenorphine |
Injection |
Yes |
Buprenorphine |
Sublingual |
Yes |
Buprenorphine |
Transdermal |
Yes |
Bupropion |
Oral |
No |
Cabazitaxel |
Injection |
No |
Cabergoline |
Oral |
Yes |
Calcipotriol with betamethasone |
Application |
Yes |
Calcitriol |
Oral |
Yes |
Candesartan |
Oral |
Yes |
Candesartan with hydrochlorothiazide |
Oral |
Yes |
Capecitabine |
Oral |
Yes |
Captopril |
Oral |
Yes |
Carbamazepine |
Oral |
Yes |
Carbimazole |
Oral |
No |
Carbomer |
Application to the eye |
Yes |
Carboplatin |
Injection |
Yes |
Carvedilol |
Oral |
Yes |
Cefaclor |
Oral |
Yes |
Cefalexin |
Oral |
Yes |
Cefalotin |
Injection |
No |
Cefazolin |
Injection |
Yes |
Cefepime |
Injection |
Yes |
Cefotaxime |
Injection |
Yes |
Ceftriaxone |
Injection |
Yes |
Cefuroxime |
Oral |
Yes |
Celecoxib |
Oral |
Yes |
Certolizumab pegol |
Injection |
Yes |
Chorionic gonadotrophin |
Injection |
Yes |
Ciclosporin |
Oral |
Yes |
Ciclosporin |
Application to the eye |
No |
Cimetidine |
Oral |
No |
Cinacalcet |
Oral |
No |
Ciprofloxacin |
Application to the eye |
Yes |
Ciprofloxacin |
Oral |
Yes |
Cisplatin |
Injection |
Yes |
Citalopram |
Oral |
Yes |
Clarithromycin |
Oral |
Yes |
Clindamycin |
Oral |
Yes |
Clomifene |
Oral |
No |
Clomipramine |
Oral |
Yes |
Clonazepam |
Oral |
Yes |
Clonidine |
Oral |
Yes |
Clopidogrel |
Oral |
Yes |
Clopidogrel with aspirin |
Oral |
Yes |
Clozapine |
Oral |
Yes |
Codeine with paracetamol |
Oral |
Yes |
Colchicine |
Oral |
Yes |
Cromoglycic acid |
Inhalation by mouth |
Yes |
Cyproterone |
Oral |
Yes |
Darunavir |
Oral |
No |
Dasatinib |
Oral |
No |
Deferasirox |
Oral |
No |
Desferrioxamine |
Injection |
Yes |
Desvenlafaxine |
Oral |
Yes |
Dexamethasone |
Application to the eye |
No |
Dexamethasone |
Implantation |
No |
Dexamethasone |
Injection |
No |
Dexamethasone |
Oral |
Yes |
Dexamethasone with framycetin and gramicidin |
Application to the ear |
Yes |
Diazepam |
Oral |
Yes |
Diclofenac |
Oral |
Yes |
Dicloxacillin |
Oral |
Yes |
Digoxin |
Oral |
Yes |
Diltiazem |
Oral |
Yes |
Dimethyl fumarate |
Oral |
No |
Diphenoxylate with atropine |
Oral |
Yes |
Dipyridamole with Aspirin |
Oral |
No |
Docetaxel |
Injection |
Yes |
Domperidone |
Oral |
No |
Donepezil |
Oral |
Yes |
Dorzolamide |
Application to the eye |
Yes |
Dorzolamide with timolol |
Application to the eye |
Yes |
Dosulepin |
Oral |
Yes |
Doxorubicin |
Injection/intravesical |
Yes |
Doxorubicin - pegylated liposomal |
Injection |
Yes |
Doxycycline |
Oral |
Yes |
Duloxetine |
Oral |
Yes |
Dutasteride |
Oral |
Yes |
Dutasteride with tamsulosin |
Oral |
Yes |
Electrolyte replacement, oral |
Oral |
Yes |
Enalapril |
Oral |
Yes |
Enalapril with hydrochlorothiazide |
Oral |
Yes |
Enoxaparin |
Injection |
Yes |
Entecavir |
Oral |
Yes |
Epirubicin |
Injection/intravesical |
Yes |
Eplerenone |
Oral |
Yes |
Epoprostenol |
Injection |
Yes |
Eprosartan |
Oral |
Yes |
Erlotinib |
Oral |
No |
Erythromycin |
Oral |
Yes |
Escitalopram |
Oral |
Yes |
Esomeprazole |
Oral |
Yes |
Esomeprazole and clarithromycin and amoxicillin |
Oral |
Yes |
Estradiol |
Oral |
Yes |
Estradiol |
Transdermal |
Yes |
Estradiol |
Vaginal |
No |
Etanercept |
Injection |
Yes |
Etoposide |
Injection |
Yes |
Etoposide |
Oral |
Yes |
Everolimus |
Oral |
Yes |
Exemestane |
Oral |
Yes |
Ezetimibe |
Oral |
Yes |
Ezetimibe and rosuvastatin |
Oral |
Yes |
Ezetimibe with atorvastatin |
Oral |
Yes |
Ezetimibe with simvastatin |
Oral |
Yes |
Famciclovir |
Oral |
Yes |
Famotidine |
Oral |
Yes |
Felodipine |
Oral |
Yes |
Fenofibrate |
Oral |
Yes |
Fentanyl |
Buccal |
Yes |
Fentanyl |
Transdermal |
Yes |
Fentanyl |
Sublingual |
Yes |
Filgrastim |
Injection |
Yes |
Fingolimod |
Oral |
No |
Flecainide |
Oral |
Yes |
Flucloxacillin |
Injection |
Yes |
Flucloxacillin |
Oral |
Yes |
Fluconazole |
Injection |
Yes |
Fluconazole |
Oral |
Yes |
Fludarabine |
Injection |
Yes |
Fludarabine |
Oral |
No |
Fludrocortisone |
Oral |
No |
Fluorouracil |
Injection |
Yes |
Fluoxetine |
Oral |
Yes |
Flutamide |
Oral |
No |
Fluticasone propionate |
Inhalation by mouth |
Yes |
Fluticasone propionate with salmeterol |
Inhalation by mouth |
Yes |
Fluvastatin |
Oral |
No |
Fluvoxamine |
Oral |
Yes |
Folinic acid |
Injection |
Yes |
Folinic acid |
Oral |
No |
Follitropin alfa |
Injection |
Yes |
Follitropin beta |
Injection |
No |
Fosaprepitant |
Injection |
No |
Fosinopril |
Oral |
Yes |
Fosinopril with hydrochlorothiazide |
Oral |
Yes |
Fulvestrant |
Injection |
No |
Furosemide |
Injection |
No |
Furosemide |
Oral |
Yes |
Gabapentin |
Oral |
Yes |
Galantamine |
Oral |
Yes |
Ganciclovir |
Injection |
Yes |
Ganirelix |
Injection |
No |
Gefitinib |
Oral |
Yes |
Gemcitabine |
Injection |
Yes |
Gemfibrozil |
Oral |
Yes |
Gentamicin |
Application to the eye |
No |
Gentamicin |
Injection |
No |
Glatiramer |
Injection |
No |
Glibenclamide |
Oral |
No |
Gliclazide |
Oral |
Yes |
Glimepiride |
Oral |
Yes |
Glipizide |
Oral |
Yes |
Glyceryl trinitrate |
Buccal/sublingual |
Yes |
Glyceryl trinitrate |
Transdermal |
Yes |
Granisetron |
Injection |
Yes |
Granisetron |
Oral |
No |
Hydrochlorothiazide with amiloride |
Oral |
No |
Hydrocortisone |
Application |
Yes |
Hydrocortisone |
Application to the eye |
No |
Hydrocortisone |
Injection |
Yes |
Hydrocortisone |
Oral |
Yes |
Hydrocortisone |
Rectal |
No |
Hydromorphone |
Injection |
Yes |
Hydromorphone |
Oral |
Yes |
Hydroxocobalamin |
Injection |
Yes |
Hydroxycarbamide |
Oral |
Yes |
Hydroxychloroquine |
Oral |
Yes |
Hyoscine |
Injection |
Yes |
Hypromellose |
Application to the eye |
Yes |
Hypromellose with carbomer 980 |
Application to the eye |
Yes |
Hypromellose with dextran |
Application to the eye |
Yes |
Ibuprofen |
Oral |
Yes |
Icatibant |
Injection |
No |
Idarubicin |
Injection |
Yes |
Imatinib |
Oral |
Yes |
Imipramine |
Oral |
Yes |
Imiquimod |
Application |
Yes |
Indapamide |
Oral |
Yes |
Indometacin |
Oral |
Yes |
Infliximab |
Injection |
Yes |
Insulin glargine |
Injection |
Yes |
Interferon beta-1b |
Injection |
No |
Ipratropium |
Inhalation |
Yes |
Ipratropium |
Inhalation by mouth |
No |
Irbesartan |
Oral |
Yes |
Irbesartan with hydrochlorothiazide |
Oral |
Yes |
Irinotecan |
Injection |
Yes |
Iron polymaltose complex |
Injection |
No |
Isosorbide dinitrate |
Oral |
No |
Isosorbide mononitrate |
Oral |
Yes |
Isotretinoin |
Oral |
Yes |
Itraconazole |
Oral |
Yes |
Ivabradine |
Oral |
Yes |
Ketoprofen |
Oral |
Yes |
Labetalol |
Oral |
Yes |
Lacosamide |
Oral |
No |
Lamivudine |
Oral |
Yes |
Lamivudine with zidovudine |
Oral |
Yes |
Lamotrigine |
Oral |
Yes |
Lanreotide |
Oral |
No |
Lansoprazole |
Oral |
Yes |
Latanoprost |
Application to the eye |
Yes |
Latanoprost with timolol |
Application to the eye |
Yes |
Leflunomide |
Oral |
Yes |
Lenalidomide |
Oral |
No |
Lercanidipine |
Oral |
Yes |
Letrozole |
Oral |
Yes |
Levetiracetam |
Oral |
Yes |
Levodopa with carbidopa |
Intra-intestinal |
No |
Levodopa with carbidopa |
Oral |
Yes |
Levodopa with carbidopa and entacapone |
Oral |
Yes |
Levonorgestrel with ethinylestradiol |
Oral |
Yes |
Levothyroxine |
Oral |
Yes |
Lincomycin |
Injection |
Yes |
Lisinopril |
Oral |
Yes |
Loperamide |
Oral |
Yes |
Losartan |
Oral |
Yes |
Lurasidone |
Oral |
Yes |
Macrogol 3350 |
Oral |
Yes |
Medroxyprogesterone |
Injection |
Yes |
Medroxyprogesterone |
Oral |
Yes |
Mefenamic acid |
Oral |
No |
Meloxicam |
Oral |
Yes |
Memantine |
Oral |
Yes |
Mercaptopurine |
Oral |
No |
Mesalazine |
Oral |
No |
Mesalazine |
Rectal |
No |
Metformin |
Oral |
Yes |
Methadone |
Oral |
Yes |
Methenamine |
Oral |
No |
Methotrexate |
Injection |
Yes |
Methotrexate |
Oral |
Yes |
Methyldopa |
Oral |
Yes |
Methylphenidate |
Oral |
Yes |
Methylprednisolone |
Application |
Yes |
Methylprednisolone |
Injection |
Yes |
Metoclopramide |
Injection |
No |
Metoclopramide |
Oral |
Yes |
Metoprolol |
Oral |
Yes |
Metoprolol succinate |
Oral |
Yes |
Metronidazole |
Oral |
Yes |
Mianserin |
Oral |
Yes |
Minocycline |
Oral |
Yes |
Mirtazapine |
Oral |
Yes |
Mitozantrone |
Injection |
Yes |
Moclobemide |
Oral |
Yes |
Modafinil |
Oral |
Yes |
Mometasone |
Application |
Yes |
Montelukast |
Oral |
Yes |
Morphine |
Injection |
Yes |
Morphine |
Oral |
Yes |
Moxonidine |
Oral |
Yes |
Mycophenolic acid |
Oral |
Yes |
Naloxone |
Injection |
Yes |
Naloxone |
Nasal |
No |
Naltrexone |
Oral |
Yes |
Naproxen |
Oral |
Yes |
Nebivolol |
Oral |
Yes |
Nevirapine |
Oral |
Yes |
Nicorandil |
Oral |
Yes |
Nifedipine |
Oral |
Yes |
Nitrazepam |
Oral |
Yes |
Nitrofurantoin |
Oral |
Yes |
Nizatidine |
Oral |
Yes |
Norethisterone |
Oral |
Yes |
Norethisterone with ethinylestradiol |
Oral |
Yes |
Norfloxacin |
Oral |
Yes |
Nortriptyline |
Oral |
Yes |
Octreotide |
Injection |
Yes |
Olanzapine |
Injection |
Yes |
Olanzapine |
Oral |
Yes |
Olmesartan |
Oral |
Yes |
Olmesartan with amlodipine |
Oral |
Yes |
Olmesartan with amlodipine and hydrochlorothiazide |
Oral |
Yes |
Olmesartan with hydrochlorothiazide |
Oral |
Yes |
Omalizumab |
Injection |
Yes |
Omeprazole |
Oral |
Yes |
Ondansetron |
Oral |
Yes |
Oxaliplatin |
Injection |
Yes |
Oxazepam |
Oral |
Yes |
Oxybutynin |
Oral |
Yes |
Oxybutynin |
Transdermal |
No |
Oxycodone |
Oral |
Yes |
Oxycodone |
Rectal |
No |
Paclitaxel |
Injection |
Yes |
Palonosetron |
Oral |
No |
Palonosetron |
Injection |
No |
Pamidronic acid |
Injection |
Yes |
Pantoprazole |
Oral |
Yes |
Paracetamol |
Oral |
Yes |
Paraffin |
Application to the eye |
Yes |
Paraffin with retinol palmitate |
Application to the eye |
No |
Paroxetine |
Oral |
Yes |
Pegfilgrastim |
Injection |
Yes |
Pemetrexed |
Injection |
Yes |
Perindopril |
Oral |
Yes |
Perindopril with amlodipine |
Oral |
Yes |
Perindopril with indapamide |
Oral |
Yes |
Phenoxymethylpenicillin |
Oral |
Yes |
Pilocarpine |
Application to the eye |
Yes |
Pindolol |
Oral |
No |
Pioglitazone |
Oral |
Yes |
Piroxicam |
Oral |
Yes |
Plerixafor |
Injection |
No |
Polyethylene glycol 400 with propylene glycol |
Application to the eye |
No |
Polyvinyl alcohol |
Application to the eye |
Yes |
Pomalidomide |
Oral |
No |
Posaconazole |
Oral |
No |
Potassium chloride |
Oral |
No |
Potassium chloride with potassium bicarbonate |
Oral |
No |
Pramipexole |
Oral |
Yes |
Pravastatin |
Oral |
Yes |
Prazosin |
Oral |
Yes |
Prednisolone |
Oral |
Yes |
Prednisolone |
Rectal |
Yes |
Prednisone |
Oral |
Yes |
Pregabalin |
Oral |
Yes |
Prochlorperazine |
Oral |
Yes |
Propranolol |
Oral |
Yes |
Quetiapine |
Oral |
Yes |
Quinapril |
Oral |
Yes |
Quinine |
Oral |
No |
Rabeprazole |
Oral |
Yes |
Raloxifene |
Oral |
Yes |
Ramipril |
Oral |
Yes |
Ranitidine |
Oral |
Yes |
Rasagiline |
Oral |
Yes |
Riluzole |
Oral |
Yes |
Risedronic acid |
Oral |
Yes |
Risedronic acid and calcium |
Oral |
No |
Risperidone |
Injection |
Yes |
Risperidone |
Oral |
Yes |
Rituximab |
Injection |
Yes |
Rivastigmine |
Oral |
Yes |
Rivastigmine |
Transdermal |
Yes |
Rizatriptan |
Oral |
Yes |
Rosuvastatin |
Oral |
Yes |
Roxithromycin |
Oral |
Yes |
Salbutamol |
Inhalation |
Yes |
Salbutamol |
Inhalation by mouth |
Yes |
Selegiline |
Oral |
No |
Sertraline |
Oral |
Yes |
Sevelamer |
Oral |
Yes |
Sildenafil |
Oral |
Yes |
Simvastatin |
Oral |
Yes |
Sitagliptin |
Oral |
No |
Sitagliptin with metformin |
Oral |
No |
Somatropin |
Injection |
Yes |
Sorbitol with sodium citrate dihydrate and sodium lauryl sulfoacetate |
Rectal |
No |
Sotalol |
Oral |
Yes |
Spironolactone |
Oral |
Yes |
Sucralfate |
Oral |
No |
Sulfasalazine |
Oral |
Yes |
Sumatriptan |
Nasal |
No |
Sumatriptan |
Oral |
Yes |
Sunitinib |
Oral |
No |
Tacrolimus |
Oral |
Yes |
Tadalafil |
Oral |
Yes |
Tamoxifen |
Oral |
Yes |
Telmisartan |
Oral |
Yes |
Telmisartan with amlodipine |
Oral |
Yes |
Telmisartan with hydrochlorothiazide |
Oral |
Yes |
Temazepam |
Oral |
Yes |
Temozolomide |
Oral |
Yes |
Tenofovir |
Oral |
Yes |
Tenofovir with emtricitabine |
Oral |
Yes |
Tenofovir with emtricitabine and efavirenz |
Oral |
Yes |
Terbinafine |
Oral |
Yes |
Teriflunomide |
Oral |
Yes |
Teriparatide |
Injection |
No |
Tetrabenazine |
Oral |
No |
Timolol |
Application to the eye |
Yes |
Tiotropium |
Inhalation by Mouth |
Yes |
Tirofiban |
Injection |
Yes |
Tobramycin |
Inhalation by mouth |
No |
Tobramycin |
Application to the eye |
Yes |
Tobramycin |
Injection |
Yes |
Tobramycin |
Inhalation |
Yes |
Tocilizumab |
Injection |
Yes |
Topiramate |
Oral |
Yes |
Topotecan |
Injection |
No |
Tramadol |
Injection |
Yes |
Tramadol |
Oral |
Yes |
Trandolapril |
Oral |
Yes |
Tranexamic acid |
Oral |
Yes |
Trastuzumab |
Injection |
Yes |
Triamcinolone |
Application |
Yes |
Triamcinolone |
Injection |
No |
Triamcinolone with neomycin, gramicidin and nystatin |
Application to the ear |
Yes |
Trimethoprim |
Oral |
Yes |
Trimethoprim with sulfamethoxazole |
Oral |
Yes |
Tropisetron |
Injection |
No |
Ursodeoxycholic acid |
Oral |
Yes |
Valaciclovir |
Oral |
Yes |
Valganciclovir |
Oral |
Yes |
Valproic acid |
Oral |
Yes |
Valsartan |
Oral |
Yes |
Valsartan with hydrochlorothiazide |
Oral |
Yes |
Vancomycin |
Injection |
Yes |
Vancomycin |
Oral |
Yes |
Varenicline |
Oral |
No |
Venlafaxine |
Oral |
Yes |
Verapamil |
Oral |
Yes |
Vincristine |
Injection |
No |
Vinorelbine |
Injection |
Yes |
Vinorelbine |
Oral |
Yes |
Voriconazole |
Oral |
Yes |
Ziprasidone |
Oral |
Yes |
Zoledronic acid |
Injection |
Yes |
Zolmitriptan |
Oral |
Yes |
Zonisamide |
Oral |
Yes |